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Basic Pharmacokinetics and Pharmacodynamics: An Integrated Textbook and Computer Simulations, by Sara E. Rosenbaum
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With its clear, straightforward presentation, this text enables you to grasp all the fundamental concepts of pharmacokinetics and pharmacodynamics. This will allow you to understand the time course of drug response and dosing regimen design. Clinical models for concentration and response are described and built from the basic concepts presented in earlier chapters. Your understanding of the material will be enhanced by guided computer exercises conducted on a companion website. Simulations will allow you to visualize drug behavior, experiment with different dosing regimens, and observe the influence of patient characteristics and model parameters. This makes the book ideal for self-study.
By including clinical models of agonism, indirect drug effects, tolerance, signal transduction, and disease progression, author Sara Rosenbaum has created a work that stands out among introductory-level textbooks in this area.You'll find several features throughout the text to help you better understand and apply key concepts:
Three fictitious drugs are used throughout the text to progressively illustrate the development and application of pharmacokinetic and pharmacodynamic principles
Exercises at the end of each chapter reinforce the concepts and provide the opportunity to perform and solve common dosing problems
Detailed instructions let you create custom Excel worksheets to perform simple pharmacokinetic analyses
Because this is an introductory textbook, the material is presented as simply as possible. As a result, you'll find it easy to gain an accurate, working knowledge of all the core principles, apply them to optimize dosing regimens, and evaluate the clinical pharmacokinetic and pharmacodynamic literature.
- Published on: 2011-04-11
- Binding: Printed Access Code
- 352 pages
Review
“I could recommend Rosenbaum’s book for pharmacology students because it is written from �a perspective of drug action . . . Overall, this is a well-written introduction to PK/PD that may fill a small niche in a well-served market. “� (British Toxicology Society Newsletter, 1 June 2012)
"In summary, I believe that this book is successful in what it sets out to do. For those readers who are interested in getting to grips with the basics of the time course of onset, offset and extent of drug effects then this is the book for you. I am certainly recommending this book for my graduate students." (British Journal of Clinical Pharmacology, 2011)"A readable font size, good quality paper and a stout binding make this an excellent offering ... This is an ideal textbook for those starting out on the pharmacokinetic trail and also for use as a reference book for those who delve occasionally into this subject." (International Society for the Study of Xenobiotics, 1 April 2012)
"In short, this is a thorough and well-designed presentation and development of key concepts in pharmacokinetics and pharmacodynamics. It is a very useful textbook, and one that I would be comfortable using in both medical and graduate teaching." (Doody's, 21 October 2011)
Review
"Unlike other basic textbooks that cover only pharmacokinetics, the author has done justice to the title of the book by covering pharmacodynamics. Pharmacodynamics is covered in greater depth than other books in the same category. What makes the book to stand out is that the author has nicely blended the concepts of receptor theory from classical pharmacology with the modern science of PK/PD.... The book truly helps readers to understand the science of pharmacokinetics and drug action. The Excel-based simulation exercises incorporated into the text helps the reader to put his/her learning into practice, albeit in a virtual environment.... The book is strongly recommended for use in undergraduate studies of PK/PD, and by those in drug research interested in having a basic understanding of the science of PK/PD."
—Ene Ette, PhD, Anoixis Corporation
"Sara Rosenbaum's book is a thoroughly modern approach to pharmacokinetics and pharmacodynamics. It is well written and well thought out – a blend of pharmacokinetic-pharmacodynamic theory and modeling/analysis concepts. The pharmacodynamic models are up to date with recent advances in the field, such as tolerance, indirect, and basic disease progression models, being presented. The web page simulations were fun to play around with allowing the user to change the model parameters and see how the results change. Rather than being a dry subject with just endless equations, the connection between the web-based simulations and the book allows the reader to be engaged and understand the subject with greater ease."
—Peter L. Bonate, PhD, author of Pharmacokinetic-Pharmacodynamic Modeling and Simulation
From the Back Cover
Interactive Computer Simulations Enable You to Quickly Learn and Apply New Skills
With its clear, straightforward presentation, this text enables you to grasp all the fundamental concepts of pharmacokinetics and pharmacodynamics. This will allow you to understand the time course of drug response and dosing regimen design. Clinical models for concentration and response are described and built from the basic concepts presented in earlier chapters. Your understanding of the material will be enhanced by guided computer exercises conducted on a companion website. Simulations will allow you to visualize drug behavior, experiment with different dosing regimens, and observe the influence of patient characteristics and model parameters. This makes the book ideal for self-study.
By including clinical models of agonism, indirect drug effects, tolerance, signal transduction, and disease progression, author Sara Rosenbaum has created a work that stands out among introductory-level textbooks in this area.You'll find several features throughout the text to help you better understand and apply key concepts:
Three fictitious drugs are used throughout the text to progressively illustrate the development and application of pharmacokinetic and pharmacodynamic principles
Exercises at the end of each chapter reinforce the concepts and provide the opportunity to perform and solve common dosing problems
Detailed instructions let you create custom Excel worksheets to perform simple pharmacokinetic analyses
Because this is an introductory textbook, the material is presented as simply as possible. As a result, you'll find it easy to gain an accurate, working knowledge of all the core principles, apply them to optimize dosing regimens, and evaluate the clinical pharmacokinetic and pharmacodynamic literature.
Most helpful customer reviews
2 of 2 people found the following review helpful.
Great book for learning PK/PD concepts and their applications
By R.Narwal
"Basic Pharmacokinetics and Pharmacodynamics: An Integrated Text Book and Computer Simulation" is a very finely crafted comprehensive introduction to PK/PD concepts and their practical applications using PK/PD simulations. Author covered both PK and PD in fair amount of details and further complemented them with PK/PD simulations (extremely helpful!!!) to maximize the understanding on how these concepts are implemented in real world scenarios. The book is organized in a thoughtful way with clear objectives and goals. The text is simple, clear and straight forward to follow. The author first provides thorough understanding of PK and then delves into PD followed by some advanced PK/PD models.
Author provided adequate number of equations and supportive derivations to clearly explain the mathematics behind useful PK/PD models. The appendices further emphasize on some useful calculations and practice sessions. Overall, all concepts are well explained and illustrated with PK/PD simulations. I highly recommend this book to graduate students, health care professionals, industrial pharmacologists and PK/PD scientists.
1 of 1 people found the following review helpful.
If you really want to learn about Pharmacokinetics/dynamics-This is where you should start
By Nermeen
To begin with, if big words, unexplained diagrams, unemphasized important concepts and unexplained processes frustrate and cause you long nights of studying, then here is why this book may be a great choice for you. Well, I am a pharmacy student who learns only when things are taught to me in a simple and clear manner. I do not randomly understand things on my own! (I hope we are all in the same boat) Upon opening this book, from page one, everything was explained. The author does not assume you know concepts such as rate processes, rather she explains them to you to assure that you know them and, at the same time, to refresh your memory of then! Everything the author discusses is explained in the book. Important concepts are repeated and emphasized....they will POP out at you! Diagrams to help you understand concepts are included numerous times per chapter, captions and explanations are included to guide you through the graphs/diagrams. The chapters are very related to each other, so the knowledge aquired from one chapter will be related to the knowledge aquired from the next. The author includes appendixes to explain how to use programs such as Excel to be able to create your own graphs (you do not have to waste your time browsing Google!) Furthermore, the book is very light in weight...you will not dread bringing it to class everyday! (In fact this is the most light weight textbook I own). One more important thing: the chapters are CONCISE and straight to the point...no unnecessary information is included. Each chapter is fairly short and easy to read...you will not be afraid to pursue reading this book.
1 of 1 people found the following review helpful.
Pharmacist
By jahern
This textbook provides a very clear explanation of basic pharmacokinetic and pharmacodynamic concepts. It is well illustrated. This book serves as a welcomed alternative to other texts that emphasize mathematical rigor at the expense of more intuitive explanations. I would highly recommended this book for pharmacy students as well as for other health care professionals who are interested in learning more about the basic principles that govern drug dosing and administration.
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